Abstract
Background: Alopecia areata is an inflammatory, autoimmune, non-scarring, common patchy, hair-loss condition. Many treatment
lines are used to treat alopecia areata, but all are palliative. Alternative medicine, like aromatherapy is expected to promote hair
growth, but they are still lacking the scientific basis. Hemp oil is one of the aromatherapies that comprises polyunsaturated fat
in approximately 76% involving “essential fatty acids” mainly omega-6 fatty acids” and lesser amount of “omega-3 fatty acids.”
Objective: The aim of this study was to evaluate hemp seed oil effect in the treatment of patients with alopecia areata. Materials and
Methods: This was a clinical trial planned to evaluate the efficacy of hemp seed oil in 20 patients with localized alopecia areata for
2 months. Plant material is hemp oil extract, applied at night daily for 2 months. Regrowth of terminal hair was evaluated by clinically
and by trichoscope examination to evaluate the pathologic changes response. The assessment was done at 0, 4, and 8 weeks of the
treatment. Results: After 8 weeks of the treatment, the response was marked in five (25%) patients, moderate in eight (40%) patients,
and mild in two (10%) patients. Five (25%) patients revealed no response. There was a significant increase in the response of patients
who were under the marked improvement group between 4 and 8 weeks of treatment (P < 0.05). Conclusion: Hemp seed oil can be
considered as a promising therapeutic agent for localized alopecia areata. Additional clinical trials are advised to adjust the dose and
determine the period of time, which is required to obtain a better result.
Keywords: Alopecia areata, aromatherapy, hemp seed oils, pathologic criteria
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27-Apr-2023
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