Background: Cryptococcus neoformans, the causative agent of cryptococcosis, is a common encapsulated
fungus that can cause a scope of sicknesses. Inhalation of organisms is the standard course of the disease
that may stay spread to the lungs or experience hematogenous disseminations and reach to any organ
through the body. Objective: The goal of this study was to determine the pulmonary Cryptococcosis in a
specimen of immune compromised patients by utilizing traditional and molecular strategies. Methods:
This study included a total of two hundred (n=200) clinical samples from 100 immuno compromised
patients and control group included 100 samples from immune competent individuals were enrolled in
this study during the period from the January2015 to February 2016. Result: Among those 100 immune
compromised patients 43 (43%) were males and 57 (57%) were females , their mean ages was 54.56
±16.46 years which ranged from 16 to 90 years, compared with 100 samples from apparently healthy
individuals used as a control group. Out of 20 patients were PCR positive for pulmonary Cryptococcus’s
12(60%) were females and 8 (40%) were males. Five (5%) samples out of 100 immuno compromised
patients were nigrosine stain positive; Three out of 100 samples were culture positive for C. neoformans.
Conclusion: diagnosis and treatment of pulmonary cryptococcosis are as yet difficult. In any case, with
early diagnosis and appropriate management, most non-AIDS patients with pulmonary cryptococcosis
have a good prognosis
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2017
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