ABSTRACT
Type 1 diabetes mellitus is an autoimmune disease in which the pancreas is unable to respond to secretagogue
stimulation with appropriate insulin secretion. Hyperglycemia develops when more than 70-90% of the insulinproducing
beta cells are destroyed. An autoimmune destructive process, which plays a central role in the
development of T1DM, is facilitated by the subject’s own genetic susceptibility and non-genetic factors. Nongenetic
factors include viral infections, toxic chemicals, and others. During recent years, there has been increasing
interest in the immunomodulating actions of vitamin D in T1DM and other autoimmune diseases.
The current study was performed to find out the relationship of vitamin D deficiency in children with type 1
diabetes mellitus to the control group, and to find out the relationship of vitamin D deficiency at various stages of
T1DM, at onset, at honeymoon period and on long duration, with there correlation to FBS, HbA1C, C-peptide and
PTH levels.
A prospective study was conducted from November, 2013 to October, 2014. The study group included One
hundred and twelve children, 83 patients and 29 children of healthy control group, their age ranged between
(1year-14years). Patients with T1DM group were divided into three sub groups as follow: [newly onset diabetes
(n=29), Honeymoon diabetes (n=25), long term diabetes (n=29)]. The study included measurements HbA1c, Cpeptide,
and 25(OH)D. Statistical analysis done by using Statistical Package for the Social Sciences (SPSS)
version 17.
The level of 25(OH)D was deficiency in 34.3% of children with T1DM, and only in 4% of control andthe mean
level of 25(OH)D were among patients with newly onset and honeymoon DM patients groups (76.76±12.2)
(63.0±14.1) respectively at P value=<0.001, while in honeymoon and long duration patients groups the mean
levels of 25(OH)D were (76.76±12.2) (71.32±4.82) respectively at P value=0.001.
The prevalence of vitamin D deficiency in diabetic childrenis was considerably high in comparison to control, and
vitamin D was low at onset followed by long duration of T1DM, but higher at honey moon period.
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2014Dec
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