ABSTRACT
Osteoarthritis (OA) is a degenerative joint disease, occurring primarily in older persons, characterized by erosion of the
articular cartilage, hypertrophy of bone at the margins (i.e., osteophytes), subchondral sclerosis, and a range of
biochemical and morphological alterations of the synovial membrane and joint capsule. In osteoarthritis free radicals
may act as triggering factor for degenerative changes seen in cartilage. Oxidative stress leads to increased risk for
osteoarthritis but the precise mechanism remains unclear. Sialic acid concentration varies physiologically with age, but
its level may also be influenced by such condition as inflammation. The aim of this study was to investigate the changes
in the serum sialic acid levels (TSA and LSA), β-Carotene and super oxide dismutase (SOD) in patients with knee
osteoarthritis. In this study 96 subjects divided into four groups, 33 patients with obese Knee OA and 25 patients non
obese Knee OA, their age range (32-78). The other 38 subjects age and sex matched healthy subjects were studied as
controls include 23 obese and 15 non obese. This study was conducted in AL-Kadhemiya Teaching Hospital during the
period from October 2011 to April 2012. Serum total sialic acid level, lipid sialic acid, serum β-Carotene and serum
SOD were determined. A significant increase in serum sialic acid (TSA & LSA) levels were observed, while there were
a significant decrease in serum β-Carotene and SOD levels in patients with knee osteoarthritis when compared to healthy
controls. The results of our study suggest higher oxygen free radical production, evidenced by decreased SOD and β-
Carotene levels support to the oxidative stress in knee osteoarthritis. The increase of serum TSA and LSA levels is
associated positively with the presence of inflammation and could be suggested as one of the many markers for Knee
osteoarthritis.
(FULL ARTICLE LINK) Read more ...
Vol. 8, No. 3, pp. 3029-3033, October 2014
|
|
|
