Patients with CL have a strong type 1 immune response to Leishmania antigen, with high production of IFN-γ and TNF-α. Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. IL-27 is a cytokine that can initiate a Th1 response but can also regulate inflammatory response. This study aims to assess the role of IL-17 and IL-27 in cutaneous leishmaniasis to identify its role in disease progression. This study involved 48 (CL) patients and 16 healthy control. Smear stained by Geimsa stain, also swab was taken for culturing. Serum were obtain to measure IL-17 and IL-27 by ELISA method. The results indicate a highly significant increase in the serum level of IL-17 in CL patients (78.36±6.28 pgml), no significant increase in the serum level of IL-27 in CL patients (17.81±1.96 pgml) when compare with control (21.01±2.77 pgml). In other hand, statistically significant important lower in serum level of IL-17A associated with ulcerative lesions 53.42±29.11 pg/ml compared with absence of ulceration, while increase in serum level of IL-27 with ulcerative lesions 21.75±19.34 pg/ml compared with absence of ulceration. The study found that IL-17A and IL-27 associated with progression CL infection
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International Journal of Advanced Research (2015), Volume 3, Issue 6, 267-270
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