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EVALUATION OF IL-2, IL-10 AND IFN-GAMMA IMMUNE EXPRESSION IN LIVER AND SPLEEN AFTER TREATMENT OF EXPERIMENTAL CYSTIC ECHINOCOCCOSIS
حيدر فيصل غازي
Authors : Waheeda Rasheed Ali Afrah Abdul-Ameer Sadek Haider Faisal Ghazi
Summary: We have evaluated IL-2; IL-10 and IFN-ɣ protein expression in both liver and spleen of BALB/c mice experimentally induced secondary hydatidosis and treated with different drugs. Following Intraperitonial inoculation of Echinococcus granulosus-protoscolices, following the infection, mice were treated for 6 months with different drugs. The sera of the mice were screened for the biochemical enzymes. Liver and spleen were processed and paraffin embedded tissue sections were examined by immunohistochemistry for IL-2, IL-10 and IFN-gamma from different study groups. Treatment with Oxfendazole shows 93.75% efficacy, but it's more effective in combination with Praziquantel (96.7%), but it lower in combination with Albendazole 82.5% or Albandazole combined with Praziquantel 77.5%. After treatment, liver and spleen express an increased IL-2, IFN-ɣ and IL-10 proteins in treated groups and positive control group compared with control negative group. Conclusion: After successful treatment of Cystic Echinococcosis (CE) will increase IL-2 and IFN-ɣ with IL-10 reduction, this would support the hypothesis that restoration of the host cell-mediated response occurs after elimination of E. granulosus.

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22/3/2016