Aim of study is to investigate the possible effect of vitex agnus castus extracts as anti-hyperlipidemic agent in mice. The fruits of
vitex agnus castus were dried and grounded into fine powder, and extracted sequentially with Chloroform, methanol and water.
Forty eight male albino mice were fed a high cholesterol diet for 28 days to construct hyperlipidemic models. The antihyperlipidemic
activity of vitex agnus castus extracts against hyperlipidemia induced was evaluated in mice. Atorvastatin was used
as a standard. Total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels
were measured. Free radical scavenging activity has been tested by 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) to discover which extract
has the highest free radical scavenging activity and to reveal the possible mechanism of action. Compared with normal mice,
hyperlipidemic mice possessed significantly higher lipid and liver enzymes profile outcomes. After treatment with vitex agnus castus
extracts, TC, TG, LDL and VLDL in hyperlipidemic mice significantly decreased. However, Methanol extract showed the most
significant reduction regarding lipid and liver enzyme profile. Moreover, it revealed the most potent free radical scavenging activity
in comparison to water extract. The results showed that methanol fruit extract of Vitex agnus castus has potential antihyperlipidemic
activity and this may be due to the high activity in free radical scavenging capability.
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2015
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