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The Acute Toxicity of Commiphora molmol oleo-gum-resin Methanol Extract
Authors : Ghaith A. Jasim*1, Adeeb A. Al-Zubaidy2, Shallal M. Hussein1, Hayder B. Sahib
The study aimed to investigate the safety of the most biological active extract of C. molmol oleo-gum-resin in terms of blood vessel growth inhibition. The active extract was subjected to the toxicity studies; The dose that consider lethal to the 50% of the animal exposed to the extract (LD50) study of the extract was evaluated in Swiss albino mice by feeding the animals with serial doses of the extract between 1.0 to 20.0 g/kg body weight orally. Acute toxicity study in rats administered with 5000mg/kg extract, the toxicity in the animals was carried out by assessing the effects on body weight, relative organ weight, biochemical parameters and histopathological study for heart, lung, liver, kidneys, spleen, stomach and sex organs for both male and female, following oral administration of methanol extract. the LD50 value of C. molmol methanol extract was calculated from the linear regression equation and equaled to 15.504 g/kg. Serum biochemical findings show no significant differences in comparison to control. No significant body weight or relative organ weight changes occurred throughout the study, histopathology of selected organs showed no remarkable pathology. Commiphora molmol methanol extract showed No signs of toxicity were observed during the acute toxicity study and the LD50 value indicates that the extract is to be safe.

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30-06-2015.