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Variations of some biochemical markers in post-menopausal women with and without osteoporosis
عمر فاروق عبد الرشيد
Authors : Basma I. Al-Nejjar, Omar F.Abdul-Rasheed, Abbas M. Jassim, Ghassan A. Al-shamaa,
Background: Osteoporosis is a silent disease because bone loss occurs without symptoms, resulting in bone fractures and prevention of fracture is dependent on early detection. The prevalence of osteoporosis increases with age due to menopause, which results in decreased production of estradiol and other hormones, leading to reduced bone mineral density. Objective: to describe the variation of some biochemical markers and to observe if these markers could be used as simple tool to predict bone turnover due to osteoporosis, among postmenopausal women. Methods: The physical characteristics were assessed using anthropometric measurements including height, weight, and body mass index (BMI), bone mineral density (BMD) of lumbar and hip were measured by the dual-energy X-ray absorptiometry (DXA) instrument. Random urine and serum calcium, phosphate and serum alkaline phosphatase (ALP) were measured using spectrophotometric kit, while serum levels of parathyroid hormone (PTH) and estradiol (E2) were measured by Enzyme-Link Immune Sorbent Assay (ELISA) techniques in 44 postmenopausal osteoporotic women and 44 healthy women as a control group, aged 50-65 years old. The patients were selected on the basis of inclusion and exclusion criteria. They were recruited from the Al-yarmouk Teaching Hospital, Baghdad, Iraq, between October 2012 and April 2014. This case-control study was conducted at Chemistry and Biochemistry department, College of Medicine, Al-Nahrain University, Baghdad, Iraq. Results: The osteoporotic postmenopausal women had higher mean serum PTH level compared to the healthy women (57.91± 29.03 vs 44.52± 17.08 pg/ml; p=0.0099). The mean serum E2 concentration was significantly higher in healthy postmenopausal women compared to osteoporotic women (51.49± 35.18 vs 34.92± 33.98 pg/ml P=0.0272). There were no significant differences in mean values of Ca+2, P and ALP (p>0.05). There were significant increased in Urinary calcium/Creatinine ratio and Urinary phosphate/Creatinine ratio (259.7±145.33 vs 192.11±119.06 mg/g; P=0.0192); (1368.32±883.66 vs 725.64±721.22; mg/g P=0.0003) respectively, in osteoporotic postmenopausal women compared to healthy postmenopausal women. Lumbar and hip BMD were significantly lower in osteoporotic postmenopausal group as compared with healthy group ( 0.73±0.06 vs 1.13±0.08 g/cm 2; p<0.0001); (0.5± 0.1 vs 0.97± 0.09 g/cm 2; p<0.0001), respectively. Conclusion: Estradiol, parathyroid hormone, urinary Calcium and urinary phosphorus may be useful to predict a bone loss among postmenopausal women.

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1 /4 /2015