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Genetic association between human Glutathione S- transferase Omega rs4925 polymorphism and Bladder Cancer risk at Baghdad city
عمر فاروق عبد الرشيد
Authors : Saleh A.Mahmood, Omar F. Abdul-Rasheed, Salwa J. Abdullah Al-Awadi
Objective To investigate the association between Active tobacco smoking and human glutathione s transferease omega rs4925 polymorphisms in patient with bladder cancer at Baghdad city. Methods A total of histopathologically confirmed 41 bladder cancer patients and 41 age matched apparently healthy controls were recruited from February 2014 to September 2014 in a case control study conducted in Department of Chemistry and Biochemistryand DNA Research and Training Center, Al-Nahrain University.Genotyping of the GSTO1 Ala140Asp polymorphism was evaluate using a polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method. The odds ratio (OR) and 95% confidence interval (CI) were calculated as a measure of the combined effect of cigarette smoking and the GSTO1 Ala140Asp polymorphism on bladder cancer risk. Result it was founded that patients with the GSTO1 Ala/Asp and Asp/Asp genotype have no significantly increase bladder cancer risk (OR 1.66 ;95% CI =0.6834 - 4.0591). A statistically highly significant increased the bladder cancer risk was also found in ever smoker with the GSTO1 (Alal/Ala) (OR =9.6 ;95% CI=0.6834 - 4.0591) and (Ala/Asp +Asp/Asp) (OR =8 ;95% CI=2.18- 29.24) compared with never smoker Ala/Ala genotype Conclusion The study suggest that smokers having GSTO1 Ala/140Asp polymorphism could play an important role as risk factor for the development with bladder cancer.

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1 /4 /2015