ABSTRACT
This study aimed to evaluate the effect of two natural products; raspberry ketones (RK) and L-carnitine on oxidative stress
parameter and body weight in Iraqi obese patients. Sixty obese women aged 20- 40 with a BMI ≥ 30 were randomly divided into
three groups twenty patients in each; group one received raspberry ketones 500 mg capsule , the second received L-carnitine 1000
mg hard capsule and the third was control without treatment. All patients were informed about Standard diet advice (low calorie
diet) the physical activity needed. The treatment course was 12 weeks. For each group, the body weight and body mass index (BMI)
were measured at baseline and after 12 weeks; oxidative stress markers (MDA, GSH and 8-isoprostane f2α) were measured at the
same manner. The percent of reduction in body weight was highest with L-carnitine group (7.38 %) and lowest with control group
(3.79%), although, RK was (5.10%). The effects of the two drugs on changes in oxidative stress parameter were as follows: the RK
was most effective in increasing glutathione activity (37.85%) comparing to L- carnitine (26.15 %) and control group (23.92 %). While
the percent of MDA reduction parameter were sorted as RK (56.57 %) more than L-carnitine (43.31 %) and L-carnitine more than
control (26.95 %) groups. However, 8-isop f2α was (8.71%) for L-carnitine,(4.32 %) for RK and (2.49%) for control group respectively.
Raspberry ketones is the most potent anti oxidant herbal treatment among two groups and can reduce the oxidative stress in obese
patients.
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1/4/2015
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